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Originally published April 28, 2025
Last updated November 3, 2026
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Five ³Ô¹Ï¹ÙÍø experts explain common causes and how to treat them.
“The digestive system — or gastrointestinal (GI) tract — is a large network of organs, and each one is vulnerable to different conditions or illnesses,� says gastroenterologist James Buxbaum, MD. Differentiating between the many possibilities depends on location and type of pain.
Three common examples include:
Celiac: Pain and nausea after eating gluten.
Pancreatitis: Severe pain in the uppercentral abdomen.
Inflammatory bowel disease (IBD): Cramping, diarrhea (sometimes with blood) or constipation.
Treatment options: Dietary adjustments, quitting alcohol and smoking, medications.
UTIs are common in people with female urinary tracts. “It’s normal to get one or two infections a year,� says urogynecologist Elodi Dielubanza, MD. “But if you’re getting them more frequently, talk to your doctor so they can investigate the root cause. And stay hydrated — urinating flushes away UTI-causing bacteria.�
Symptoms:
Treatment: Antibiotics.
“For people who menstruate, severe pain that occurs monthly can suggest a gynecological condition such as endometriosis or fibroids,� says gynecologist Anna Reinert, MD.
Endometriosis symptoms:
Fibroid symptoms:
Treatment options: Medication, minimally invasive surgery.
Genetics, a fatty diet and blood disorders like sickle cell anemia can lead to gallstones, which “can cause inflammation or block bile flow after a fatty meal, leading to biliary colic,� says Mohd Raashid Sheikh, MD, MHA, a hepatobiliary surgeon.
Treatment: Gallbladder removal.
Urinary retention occurs when the bladder doesn’t empty completely, says a ³Ô¹Ï¹ÙÍø urologist. Causes include an enlarged prostate, uncontrolled diabetes, nerve injuries, bladder tumors or pelvic organ prolapse. It can lead to discomfort and, if untreated, affect kidney function, so seeing a doctor is important.
Treatment options: Foley catheterization, medications, surgery or pessary.
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