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Originally published September 21, 2026
Last updated September 21, 2026
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Medical providers closely supervise any patient undergoing chemotherapy to monitor how they respond to treatment. But that attention takes on added emphasis with senior patients, who tend to have more preexisting medical conditions and diseases, such as high blood pressure, kidney dysfunction and diabetes.
“How healthy seniors are, and how safe it is to proceed with chemotherapy treatments, are usually the first questions we have to answer,” says Christopher Foss, MD, a hematologist-oncologist with USC Norris Comprehensive Cancer Center, part of ԹϹ.
With senior patients, he says, “the safety and tolerability of treatment and potential side effects are definitely more at the forefront of our concerns compared to younger individuals.”
Older patients tend to take more medications to manage existing health conditions. Below, Dr. Foss discusses one concern in particular: the effects of adding chemotherapy drugs to a patient’s already complex medication regimen.
USC Norris Comprehensive Cancer Center care teams comprehensively gather information about a patient’s medical and surgical history, as well as any current medical conditions and prescriptions.
“We make sure we’re aware of all the medications our patients are taking,” Dr. Foss says.
In close collaboration with Keck Medicine pharmacists, the oncology team identifies any potential interactions between patients’ regular medications and chemotherapy drugs.
“At USC Norris, we have specialty pharmacists well-versed in chemotherapy medications,” Dr. Foss says, adding, “In terms of monitoring safety and drug interaction, we want to make sure the liver and kidneys, in particular, are healthy.”
Oncologists like Dr. Foss also collaborate with Keck Medicine nutritionists and palliative care specialists.
“We take a comprehensive approach, enlisting the help of many specialists,” he says.
After assessing patients’ health and medications, the medical team then determines if any adjustments need to be made, such as avoiding drugs that could make chemotherapy drugs less effective. For instance, patients might take medication that suppresses stomach acid production but that can also affect the absorption of chemotherapy drugs, especially oral cancer therapies.
The team may decide to adjust the dosage or number of a senior patient’s chemotherapy treatments. The frequency of the treatments also might be adjusted to allow more time for recovery between infusions.
In addition, the team determines if patients need any supportive medications to address chemotherapy’s possible side effects, such as nausea, pain or diarrhea. Some people in chemotherapy experience weight loss that can affect their blood pressure medications, which then need to be adjusted accordingly. Some oral chemotherapy drugs can lead to high blood pressure, so the team might need to tweak a patient’s blood pressure meds.
“We really make sure our patients have everything they need to support any potential side effects,” Dr. Foss says.
Patients often ask whether it’s safe to keep taking dietary supplements during chemotherapy treatment. “Generally, supplements tend not to pose any interactions with the drugs we prescribe,” Dr. Foss says.
That said, he advises patients taking supplements to get them from reputable drugstores, not websites or other sources where it’s unclear how the supplements were manufactured. Supplements with unknown ingredients could damage the liver and kidneys.
In addition to providing medical care, the USC Norris team assists with social supports that patients might need, such as transportation and equipment to get to and from their infusion appointments.
“Often, the elderly population has unique social and functional needs that we pay attention to,” Dr. Foss says. “At USC Norris Comprehensive Cancer Center, patients have access to a lot of support resources.”
The team also helps patients manage their regular medications while they’re on chemotherapy regimens, which can be very complicated. Patients might receive chemotherapy drugs for three weeks in a row and then not receive the drugs the fourth week to allow time to recuperate.
“The timing and schedule can be confusing sometimes, even for someone who’s really diligent,” Dr. Foss says.
Different strategies can help here, he says. Patients can use pill organizers so they know what medications to take on each day of the week. For medications that patients need to take multiple times a day, they can set reminder alarms on their phones. Family members and other home caregivers also can help remind patients when to take their medications.
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